|
KMID : 0984920130150020110
|
|
Journal of Skin Barrier Research
2013 Volume.15 No. 2 p.110 ~ p.110
|
|
|
Stimulation by Parabens Up-Regulate TSLP Expression in Human Normal Keratinocytes
|
|
Kim Kkot-Byeol
Lee Seung-Hi
Jang Mi-Jin
Lee Sun-A
Kim Hyun-Jung
|
|
|
Abstract
|
|
|
|
Some ingredients of dermatological formulations result in skin irritation and allergy. In particular, preservatives have been reported extensively as a cause of allergic contact dermatitis. The study focused on parabens which have been used extensively as antimicrobial preservatives in foods, drugs and cosmetics. Thymic stromal lymphopoietin (TSLP) is an IL-7 related cytokine, produced by epithelial cells, that has been linked to atopic dermatitis and asthma. TSLP expression is up-regulated in the lesions of allergic patients. Here we demonstrate a change of TSLP expression when stimulated by parabens in human normal keratinocytes. Methyl paraben(MP), propyl paraben(PP) and butyl paraben(BP) of various parabens are used widely. The study investigated the effects exposure to MP, PP and BP on keratinocytes in vitro. Normal human keratinocytes was cultured in the medium containing MP, PP and BP. The following changes were analysed: proliferating ability, TSLP mRNA expressions. MP, PP and BP decreased the proliferating ability of keratinocytes especially PP and BP affect at low concentration rather than MP. And PP and BP increase the expressions of TSLP mRNA in keratinocytes but MP doesn`t. Interestingly effect of PP and BP that increased the expressions of TSLP mRNA confirmed in allowed concentration for use in cosmetics products by Ministry of Food and Drug Safety. These results suggest that parabens which have been used in cosmetics might influence the atopic dermatitis through decreased the proliferating ability and increased the expressions of TSLP mRNA of keratinocytes.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|